Specialties:

Biography:

Lance Parton, MD, FAAP
Professor-Pediatrics Assoc.
Chief-NICU Pulmonary Medicine

Positions:
Professor of Pediatrics
Division of Newborn Medicine
Division of Pediatric Pulmonology
Associate Professor of Obstetrics and Gynecology, and Anesthesiology

Education & Trianing:
Undergraduate: University of California, Berkeley, CA-B.S. Chemistry; B.S. Genetics
Graduate: New York Medical College, Valhalla, NY-M.D.
Pediatric Internship: Georgetown University Hospital, Washington, D.C.
Pediatric Residency: Children’s Hospital of Los Angeles, L.A., CA
Pediatric Chief Residency: Children’s Hospital of Los Angeles, L.A., CA
Fellowship: Neonatal-Perinatal Medicine and Pediatric Pulmonology, Children’s Hospital of Los Angeles, L.A., CA; Mentor-Dr. David Warburton.
Post-doctoral Fellowship: Molecular Pharmacology-S.U.N.Y. at Stony Brook, Dr. Sidney Strickland.

Professional Interests:
Clinical: All clinical conditions affecting the fetus and newborn, with particular interest in pulmonary conditions, and the variety of non-invasive and invasive modes of ventilation utilized to treat these conditions, including high-frequency jet ventilation, high frequency oscillatory ventilation and the VDR-4.

Research: Translational investigations involving the genetic foundations of conditions affecting preterm infants, particularly bronchopulmonary dysplasia (BPD) and patent ductus arteriosus (PDA). Also interested in genetic foundations of conditions that may make mothers susceptible to delivering prematurely.

Teaching: Active in teaching neonatal fellows, pediatric residents, medical students, undergraduates, and high school students.

Administrative: Active in a number of committees on campus, including the Faculty Senate, Professionalism and Integrity Committee, Second Year Advancement Committee; Credentials Committee, Critical Care Committee, Medical Operations Committee, and Pediatric Residency and Neonatal Fellowship Educational
Committees.

Leadership: Associate Chief of the Regional NICU; Director, Pulmonary Medicine Section; Past President of New York Chapter 3 of the American Academy of Pediatrics.

Selected Publications
Parton LA, Warburton D, Laug W. Plasminogen Activator Inhibitor Type 1 Production by Rat Type II Pneumocytes in culture. Am J Resp Cell and Mol Biol, 6:133-139, 1992.

Singhal KK and Parton LA. Plasminogen activator activity in preterm infants with respiratory distress syndrome: relationship to the development of bronchopulmonary dysplasia. Ped Research, 39(2):229-235, 1996.

Munshi UK, Niu JO, Siddiq MM, LA Parton. Elevation of Interleukin-8 and Interleukin-6 Precedes the Influx of Neutrophils in Tracheal Aspirates from Preterm Infants who develop Bronchopulmonary Dysplasia. Pediatr Pulmonol 24:331-336, 1997.

Niu JO, Siddiq MM, and LA Parton. Early increase in endothelin-1 in tracheal aspirates of preterm infants: correlation with bronchopulmonary dysplasia. J Pediatrics, 132: 965-70, 1998.

Kakkera DK, Siddiq MM, Parton LA. Interleukin-1 Balance in the Lungs of Preterm Infants Who Develop Bronchopulmonary Dysplasia. Biol Neonate 87: 82-90, 2005.

Fuks A, Parton LA, Polavarapu S, Netta D, Strassberg S, Godi I, Hsu C-D. Polymorphism of Fas and Fas Ligand in Preterm Premature Rupture of Membranes in Singleton Pregnancies. Am J Obstet Gynecol 193(3):1132-6, 2005.

Parton LA, Strassberg SS, Qian D, Galvin-Parton PA, Cristea IA. The Genetic basis of bronchopulmonary dysplasia. Front Bioscience 11:1854-60, 2006.

Strassberg SS, Cristea IA, Qian D, Parton LA. Single nucleotide polymorphisms of tumor necrosis factor-α and the susceptibility to Bronchopulmonary Dysplasia. Pediatr Pulmonol 42(1):29-36, 2007.

DeCastro M, El-Khoury N, Parton L, Ballabh P, LaGamma EF. Postnatal betamethasone versus dexamethasone in premature infants with bronchopulmonary dysplasia: a pilot study. J Perinatol 2009;29(4):297-304.

Robinson R, Hsu C-D, Chesebro A, Nguyen J, Ali N, Maramreddy H, Parton LA. A single nucleotide polymorphism (-670) of the maternal Fas gene is associated with Intrauterine Growth Restriction. Am J Obstet Gynecol 2009;201:620.e1-4.

Mercado VV, Cristea I, Ali N, Pham C, Buescher E, Yang J, Fisher J, Maramreddy H, Calo J, Strassberg S, Parton LA. Does the type of Surfactant cause a differential Pro-Inflammatory Response in Preterm Infants with Respiratory Distress Syndrome? Advances in Therapy 2010;27(7):476-82.

Haleem A, Zia MT, Mishra R, Parton LA, Stringel G, La Gamma EF. Bedside lung mechanics predict survival in hypoplastic lung disease, Am J Perinatol 2011;28(4):305-14. (Epub 2010 Nov 29).

Assefa D, Amin N, Dozor AJ, Parton LA. Attenuated interleukin-8/leukocyte immunoresponse in preterm infants compared with term infants hospitalized with respiratory syncytial virus bronchiolitis: a pilot study, Hum Immunol 2011;72(9):708-11. (Epub 1 June 2011).

Polavarapu SS, Maramreddy H, Parton LA, Hsu C-D. Are placental Fas and Fas ligand gene polymorphisms associated with preeclampsia? Pregnancy Hypertension: An International J of Women’s Cardiovascular Health 2013;3:34-38 (Epub Sept 2012).

Hurley E, Krishnan S, Parton LA, Dozor AJ. Perspectives of neonatologists and pediatric pulmonologists on the management and prognosis of children with Trisomy 18, Am J Med Genetics 2014;164A(10):2551-6 (doi:10.1002/ajmg.a.36687) (Epub Aug 2014).